Cellular Respiration: Stages, ATP Production, and Electron Transport

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  • Cellular respirationThe process by which cells break down glucose to produce ATP; overall equation is C6H12O6 + 6O2 → 6CO2 + 6H2O + ~32 ATP
  • GlycolysisAnaerobic process in the cytoplasm that splits one glucose into two pyruvate molecules, producing a net gain of 2 ATP and 2 NADH
  • Krebs cycle (citric acid cycle)Takes place in the mitochondrial matrix; each turn releases 2 CO2 and generates 3 NADH, 1 FADH2, and 1 ATP; turns twice per glucose molecule
  • Electron transport chainEmbedded in the inner mitochondrial membrane; NADH and FADH2 donate electrons that pump protons into the intermembrane space, with oxygen as the final electron acceptor; produces approximately 26–28 ATP
  • ChemiosmosisMovement of protons across the inner mitochondrial membrane through ATP synthase, which uses the proton gradient to phosphorylate ADP into ATP
  • ATP synthaseEnzyme embedded in the inner mitochondrial membrane that catalyzes oxidative phosphorylation by using proton flow to drive ATP synthesis
  • Lactic acid fermentationAnaerobic pathway in muscle cells that converts pyruvate to lactate, regenerating NAD+ to allow glycolysis to continue
  • Alcoholic fermentationAnaerobic pathway in yeast that converts pyruvate into ethanol and CO2
  • ATP (adenosine triphosphate)The cell's main energy currency molecule
  • NAD+ and NADHNAD+ is an electron carrier that accepts electrons and becomes reduced to NADH
  • FADH2An electron carrier that donates electrons in the electron transport chain
  • CristaeFolds of the inner mitochondrial membrane that increase surface area for electron transport chain reactions
  • AerobicRequiring oxygen
  • AnaerobicNot requiring oxygen
  • Substrate-level phosphorylationDirect ATP formation by enzyme transfer of a phosphate group to ADP, as opposed to oxidative phosphorylation